Nano Biomaterials: A promising therapeutic strategy for skin wound healing in diabetic populations?
نویسندگان
چکیده
The diabetic wound healing is a common problem faced by both physicians and surgeons. The applications of nano biomaterials opened a new way to heal diabetic wounds. There were four parts in this review. First, we introduced the concept of the nano biomaterials. Second, we summarized systematically the mechanism of the nano biomaterials used for promoting wound healing. Thirdly, the application of nano biomaterials in clinical practice was introduced. At last, we mentioned the features of diabetic wound and presented the basic and clinical researches of the nano biomaterials in diabetic wound healing.
منابع مشابه
Rapid repair of skin ulcers in diabetic rats using polycaproplactone /gelatin nanon-fiber scaffold
Introduction: Three-dimensional nano scaffolds by creating a three-dimensional structure similar to the body tissues have created a new perspective on cell culture and tissue repair. The aim of this study was to investigate the effect of polycaprolactone biodegradation scaffold (PCL) in treatment of diabetic wounds. Materials and Methods: Nano PCL-Gelatine scaffold was synthesized by electrospu...
متن کاملEngineered human vascularized constructs accelerate diabetic wound healing.
Stem cell-based therapy is emerging as a promising approach for chronic diabetic wounds, but strategies for optimizing both cellular differentiation and delivery remain as major obstacles. Here, we study bioengineered vascularized constructs as a therapeutic modality for diabetic wound healing. We developed a wound model in immunodeficient rodent and treated it with engineered vascularized cons...
متن کاملBiomaterials for Promoting Wound Healing in Diabetes
Impaired wound healing is the leading cause of non-traumatic lower limb amputation in people with diabetes mellitus. Skin substitutes engineered from biomaterials currently play an important role in the healing process of diabetic wounds, especially those wounds that fail to show progress after standard wound care. This article summarizes current developments of biomaterials used for promoting ...
متن کاملHyaluronic acid in the treatment and prevention of skin diseases: molecular biological, pharmaceutical and clinical aspects.
The glycosaminoglycan hyaluronic acid (HA), or hyaluronan, is a major component of the extracellular matrix of skin, joints, eye and many other tissues and organs. In spite of its simple structure, HA demonstrates remarkable rheological, viscoelastic and hygroscopic properties which are relevant for dermal tissue function. Biological activities in skin, however, are also due to its interaction ...
متن کاملReview Paper: Application of Hair Follicle Bulge Stem Cells in Wound Healing
Despite the significant advances in regenerative medicine, wound healing has remained a challenging clinical problem. Skin is the largest human organ with many vital functions; therefore, any damage to its normal structure should be treated as soon as possible. Easy access to skin stem cells has created a lot of excitement in therapeutic applications. “Cell therapy” is considered a novel method...
متن کامل